Surgery alone achieves comparable survival to adjuvant therapy in T4aN0M0 gingival squamous cell carcinoma with clear surgical margins: A registry-based propensity-matched analysis

For patients with T4aN0M0 GSCC and clear surgical margins, adjuvant RT/CRT did not confer a survival advantage over surgery alone, suggesting limited benefit of routine adjuvant therapy in this setting. Prospective studies are needed to validate this finding and to refine evidence-based risk stratification models.

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Publication Details

Journal
Oral Oncology
Published
2026-03-03
DOI
https://doi.org/10.1016/j.oraloncology.2026.107915
Primary Topic
Head and Neck Cancer Studies
Type
article
Field-Weighted Citation Impact
0.00
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article

Surgery alone achieves comparable survival to adjuvant therapy in T4aN0M0 gingival squamous cell carcinoma with clear surgical margins: A registry-based propensity-matched analysis

Nai-Ming Cheng, Hsin Li-Jen, Ch'ang Hui-Ju, Tsao Chung-Kan et al.
Oral Oncology
Head and Neck Cancer Studies
article

Surgery alone achieves comparable survival to adjuvant therapy in T4aN0M0 gingival squamous cell carcinoma with clear surgical margins: A registry-based propensity-matched analysis

Nai-Ming Cheng, Hsin Li-Jen, Ch'ang Hui-Ju, Tsao Chung-Kan, Li-Yu Lee, Lou Pei‐Jen, Shu-Ru Lee, Yao-Te Tsai, Wan-Ni Lin, Li-Ang Lee, Shyuang-Der Terng, Shu-Hang Ng, Chih-Yen Chien, Chi-Ying Tsai, Tzu-Chen Yen, Chun-Hung Hua, Chien-Yu Lin, Tuan-Jen Fang, Ku-Hao Fang, Chung-Jan Kang, Hung-Ming Wang, Shiang-Fu Huang, Kang-Hsing Fan, Yu-Wen Wen, Chia-Hsun Hsieh, Jin-Ching Lin, Yu-Chien Wang, Chih-Hua Yeh, Cheng Ping Wang, Chun-Ta Liao, Chih-Hung Lin
article en

Abstract

For patients with T4aN0M0 GSCC and clear surgical margins, adjuvant RT/CRT did not confer a survival advantage over surgery alone, suggesting limited benefit of routine adjuvant therapy in this setting. Prospective studies are needed to validate this finding and to refine evidence-based risk stratification models.

Oral OncologyVol. 176
National Sun Yat-sen University (TW), Chang Gung University (TW), China Medical University (TW), Chang Gung Memorial Hospital (TW), Kaohsiung Chang Gung Memorial Hospital (TW), Linkou Chang Gung Memorial Hospital (TW), China Medical University Hospital (TW), National Taiwan University Hospital (TW), Koo Foundation Sun Yat-Sen Cancer Center (TW), Chiayi Chang Gung Memorial Hospital (TW), Taipei Medical University-Shuang Ho Hospital (TW), Changhua Christian Hospital (TW)
Gender equality
Openalex Percentile: Top 34%
Head and Neck Cancer Studies
DOIOpen Access PDFOpenAlex
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