Defects in PDIA4 increase individuals’ susceptibility to congenital heart disease
Our study suggests that <i>PDIA4</i> may act as a susceptibility gene for CHD, and its deficiency may contribute to abnormal cardiac development by modulating the WNT/β-catenin signaling pathway.
Authors
- Quannan Zhuang
- Siyi Lin
- Yuan Gao (ORCID: https://orcid.org/0000-0002-9510-6515)
- Wei Sheng (ORCID: https://orcid.org/0000-0002-0532-9863)
- Yuquan Lu (ORCID: https://orcid.org/0000-0002-1486-0015)
- Shaojie Min
- Quming Zhao
- G Y Huang
- Xianghui Huang
- Zhiyu Feng
- Siyu Sun
- Jiangjie Liu
Institutions
- Children's Hospital of Fudan University (CN)
- Children’s Hospital of Fudan University Xiamen Branch (CN)
Publication Details
- Journal
- Frontiers in Genetics
- Published
- 2026-03-03
- DOI
- https://doi.org/10.3389/fgene.2026.1753969
- Primary Topic
- Endoplasmic Reticulum Stress and Disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00