Limosilactobacillus reuteri alleviates proinflammatory T-cell-mediated liver injury and transcriptomic changes in immunocompromised mice
Inflammatory lymphocytes (CD4<sup>+</sup> T cells) can perpetuate an exaggerated immune response in an immunologically naïve host. Feeding with DSM 17938 modulated T cells and allowed them to provide beneficial effects to the recipient. We observed activation of multiple genes and their interactions. These findings suggest that probiotics or probiotic-modulated T cells could be further explored as therapeutic options for autoimmune liver diseases.
Authors
- Y. Liu
- Beanna Okeugo (ORCID: https://orcid.org/0009-0004-4645-4355)
- Vaishali Harne (ORCID: https://orcid.org/0000-0002-8387-607X)
- Ana Fadhel Alvarez
- Marc Rhoads Jon
- Meng Luo (ORCID: https://orcid.org/0000-0001-8626-6456)
- Zheng Yin
- Taylor Cm
- Alexander Banerjee (ORCID: https://orcid.org/0000-0003-1649-6939)
- Melissa Munroe
- Stephen T. Wong
- Salomea Giorgberidze
- Rambabu Majji
- Kang Ho Kim
- Ji Ho Suh
- Hari Krishna Yalamanchili
Institutions
- Houston Methodist (US)
- Neurological Research Institute (US)
- Children's Nutrition Research Center at Baylor College of Medicine (US)
- Texas Children's Hospital (US)
- The University of Texas Health Science Center (US)
- Louisiana State University Health Sciences Center New Orleans (US)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-03-03
- DOI
- https://doi.org/10.3389/fimmu.2026.1713120
- Primary Topic
- NF-κB Signaling Pathways
- Type
- article
- Field-Weighted Citation Impact
- 0.00