Weight-related changes in MRI-derived measures of body composition and liver steatosis: a large-scale analysis for obesity trial design
Using MRI, relative changes in body composition and liver steatosis resulting from weight loss can inform clinical trials, including placebo arm design and power estimations. Weight changes affect body composition and liver fat and can inform obesity trial design.
Authors
- Carlos Martínez Duncker (ORCID: https://orcid.org/0000-0002-3624-1565)
- Helena Thomaides Brears
- Steve B. Heymsfield
- Louise E. Thomas
- Matthew D. Robson
- Jimmy D. Bell
- Tim Pagliaro
- Magdalena Zawadzka Nowak
- Lee M. Kaplan
- Luis Núñez
Institutions
- Pennington Biomedical Research Center (US)
- Dartmouth College (US)
- Louisiana State University (US)
- British Society of Periodontology (GB)
- Pinnacle Clinical Research (US)
- University of Westminster (GB)
Publication Details
- Journal
- International Journal of Obesity
- Published
- 2026-03-03
- DOI
- https://doi.org/10.1038/s41366-026-02037-y
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00