Impairment of Rab7-dependent STING degradation hampers HBV replication but accelerates disease progression in chronic hepatitis B comorbid with MASLD
In CHB-MASLD comorbidity, impaired Rab7 function leads to aberrant STING accumulation in macrophages, suppressing HBV replication but paradoxically accelerating liver disease progression. Targeting Rab7 to degrade excessive STING represents a novel therapeutic strategy.
Authors
- Qi Gao (ORCID: https://orcid.org/0000-0001-6230-9116)
- Awang Danzeng (ORCID: https://orcid.org/0009-0007-1175-4034)
- Feiyang Xu
- Wenhui Wu (ORCID: https://orcid.org/0000-0001-8962-4693)
- Xitang Li
- Bin-hao Zhang
- Suping Hai (ORCID: https://orcid.org/0009-0008-7943-5141)
- Xing Wang (ORCID: https://orcid.org/0000-0002-8537-7186)
- Binghui Yu (ORCID: https://orcid.org/0009-0009-8047-7231)
- Xizhe Zheng
- Junjian Hu
- Yuanyuan Wang
- Qin Ning
Institutions
- Tongji Hospital (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Gut
- Published
- 2026-03-03
- DOI
- https://doi.org/10.1136/gutjnl-2026-338065
- Primary Topic
- interferon and immune responses
- Type
- article
- Field-Weighted Citation Impact
- 0.00