Feline Cancers: Cat-aloging the Mutational Landscape

Whole-genome sequencing of nearly 500 paired tumor-normal cat tissue samples, representing 13 cancers, has uncovered strong similarities with the human oncogenome, including recurrently mutated TP53 as a driver of multiple tumor types. This is the first time the domestic feline oncogenome has been comprehensively characterized, and the human parallels support utilizing cats more frequently in comparative oncology.