Prospective Validation of the New <scp>PLS</scp> Diagnostic Criteria From <scp>PLS</scp> Natural History Study: <scp>EMG</scp> and Neurofilament Analyses
In our population, reclassification of PLS to ALS occurred at a low frequency at 1 year follow-up (7.1%). Baseline NfL was the strongest predictor in differentiating UMN dominant ALS from PLS at 1-year follow-up. Based on our data, we propose EMG and NfL criteria for enrollment in future PLS trials.
Authors
- Elman Lauren
- Yasushi Kisanuki
- Ghazala Hayat (ORCID: https://orcid.org/0000-0003-4159-6966)
- Björn Oskarsson (ORCID: https://orcid.org/0000-0002-1725-9866)
- Daragh Heitzman
- Ken Cheung
- Senda Ajroud‐Driss (ORCID: https://orcid.org/0000-0001-7627-425X)
- Rebecca Yun
- Grace E. Jang (ORCID: https://orcid.org/0009-0002-8051-7052)
- Eric J. Sorenson (ORCID: https://orcid.org/0009-0000-7773-7754)
- Michael Pulley (ORCID: https://orcid.org/0000-0003-1879-725X)
- Stephen A. Goutman (ORCID: https://orcid.org/0000-0001-8780-6637)
- Kasarskis Ej
- H. Mitsumoto
- Alex Sherman
- Stephen N. Scelsa (ORCID: https://orcid.org/0000-0002-1239-7899)
- Ikjae Lee
- Mary Kay Floeter
- Sabrina Paganoni
- Jaimin Shah
- Kelly Gwathmey
- Zachary Simmons
- Lorne Zinman
- Christina N Fournier
- Terry Heiman-Patterson
- J Americo M Fernandes
- Christen Shoesmith
- Omar Jawdat
- Wendy S Johnston
- David Walk
- Catherine Lomen-Hoerth
- Frank Diaz
- Benjamin N Hoover
- Nicholas J Maragakis
- Ali A Habib
- for the PLS NHS Study Group
Institutions
- Northwestern University (US)
- Western University (CA)
- Cedars-Sinai Medical Center (US)
- Mount Sinai Beth Israel (US)
- National Institutes of Health (US)
- University of Minnesota (US)
- Sunnybrook Health Science Centre (CA)
- Mayo Clinic (US)
- Harvard University (US)
- University of Kentucky (US)
- Johns Hopkins University (US)
- Emory University (US)
- University of Alberta (CA)
- University of California, San Francisco (US)
- Virginia Commonwealth University (US)
- Saint Louis University (ES)
- University of Michigan (US)
- Columbia University Irving Medical Center (US)
- Spaulding Rehabilitation Hospital (US)
- Johns Hopkins Medicine (US)
- Jacksonville College (US)
- The Ohio State University Wexner Medical Center (US)
- University of Florida (US)
- Massachusetts General Hospital (US)
- University of California, Irvine Medical Center (US)
- University of Kansas Medical Center (US)
- Texas Neurology (US)
- Mayo Clinic in Florida (US)
- Saint Louis University (US)
- University of Nebraska Medical Center (US)
- Columbia University (US)
- University of Pennsylvania (US)
- Penn State Milton S. Hershey Medical Center (US)
- Temple University (US)
- Florida College (US)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Muscle & Nerve
- Published
- 2026-03-02
- DOI
- https://doi.org/10.1002/mus.70192
- Primary Topic
- Amyotrophic Lateral Sclerosis Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00