Neuronal phenotypic alterations and the therapeutic potential of Anxa2 in traumatic brain injury recovery

Neurons exhibit extensive gene expression and signaling pathway modifications after TBI, and neuronal Anxa2 plays a beneficial role in behavioral recovery. Moreover, our findings suggest that multiple small-molecule compounds may serve as potential therapeutic agents targeting Anxa2, providing new insights for the development of TBI therapeutics.

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Publication Details

Journal
Brain Research Bulletin
Published
2026-03-04
DOI
https://doi.org/10.1016/j.brainresbull.2026.111810
Primary Topic
Axon Guidance and Neuronal Signaling
Type
article
Field-Weighted Citation Impact
0.00
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article

Neuronal phenotypic alterations and the therapeutic potential of Anxa2 in traumatic brain injury recovery

Weixin Xing, Yi Jin, Jiangang Liu, Zongqi Wang et al.
Brain Research Bulletin
Axon Guidance and Neuronal Signaling
article

Neuronal phenotypic alterations and the therapeutic potential of Anxa2 in traumatic brain injury recovery

Weixin Xing, Yi Jin, Jiangang Liu, Zongqi Wang, Yuanqing Zhang, Bin Zhang, Jiashuo Zhao, Hongwei Hu
article en

Abstract

Neurons exhibit extensive gene expression and signaling pathway modifications after TBI, and neuronal Anxa2 plays a beneficial role in behavioral recovery. Moreover, our findings suggest that multiple small-molecule compounds may serve as potential therapeutic agents targeting Anxa2, providing new insights for the development of TBI therapeutics.

Brain Research BulletinVol. 237
Jiangsu University (CN), Soochow University (CN), Jintan People's Hospital (CN), Second Affiliated Hospital of Soochow University (CN), Hainan 301 Hospital (CN), First Affiliated Hospital of Soochow University (CN)
Good health and well-being
Openalex Percentile: Top 36%
Axon Guidance and Neuronal Signaling
DOIOpen Access PDFOpenAlex
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Neuronal phenotypic alterations and the therapeutic potential of Anxa2 in traumatic brain injury recovery — Weixin Xing, Yi Jin, et al. · Brain Research Bulletin (2026) | TGRS Research Map | TGRS