Clinical and immunological implications of lymphocyte-activation gene 3 expression in metastatic colorectal cancer
LAG3 expression is an independent prognostic biomarker of mCRC. The distinct Galectin-9-TIM-3 signaling in LAG3⁺CD8⁺ T cells may contribute to limited therapeutic efficacy of LAG3 blockade, suggesting potential combinational immunotherapy strategies.
Authors
- Yi‐Hsuan Huang (ORCID: https://orcid.org/0000-0001-8436-2508)
- Bing-Syuan Chung
- B. W. Lin
- Ren-Hao Chan
- Chung Ta Lee
- Shang-Yin Wu
- Shang-Hung Chen
- Meng-Ru Shen
- Po-Chuan Chen
- Yu-Min Yeh
- Peng-Chan Lin
Institutions
- National Health Research Institutes (TW)
- National Cheng Kung University Hospital (TW)
Publication Details
- Journal
- Cancer Immunology Immunotherapy
- Published
- 2026-03-03
- DOI
- https://doi.org/10.1007/s00262-026-04344-9
- Primary Topic
- Galectins and Cancer Biology
- Type
- article
- Field-Weighted Citation Impact
- 0.00