Zolpidem use and the risk of arrhythmia: A nationwide population-based cohort study in Taiwan

Zolpidem use is independently associated with an increased risk of incident arrhythmia, particularly tachyarrhythmias such as paroxysmal tachycardia and atrial flutter. Clinicians should incorporate cardiac risk assessment into their prescribing decisions and consider periodic monitoring for high-risk patients. Study limitations include the observational design and the unavailability of granular dosage data.

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Publication Details

Journal
Journal of the Chinese Medical Association
Published
2026-03-03
DOI
https://doi.org/10.1097/jcma.0000000000001360
Primary Topic
Cardiovascular Syncope and Autonomic Disorders
Type
article
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article

Zolpidem use and the risk of arrhythmia: A nationwide population-based cohort study in Taiwan

Chun‐An Cheng, Jiaying Shen, Yuan Hung, Hong-Jhe Chen et al.
Journal of the Chinese Medical Association
Cardiovascular Syncope and Autonomic Disorders
article

Zolpidem use and the risk of arrhythmia: A nationwide population-based cohort study in Taiwan

Chun‐An Cheng, Jiaying Shen, Yuan Hung, Hong-Jhe Chen, C. K. Chen, Hsun Ou, W. U.Chien Chien, Brendon Stubbs, Tien-Yu Chen
article en

Abstract

Zolpidem use is independently associated with an increased risk of incident arrhythmia, particularly tachyarrhythmias such as paroxysmal tachycardia and atrial flutter. Clinicians should incorporate cardiac risk assessment into their prescribing decisions and consider periodic monitoring for high-risk patients. Study limitations include the observational design and the unavailability of granular dosage data.

Journal of the Chinese Medical Association
University of Vienna (AT), National Yang Ming Chiao Tung University (TW), King's College London (GB), Taipei Medical University Hospital (TW), Austrian Institute for Sports Medicine (AT), Keelung Chang Gung Memorial Hospital (TW), Taiwan Nurses Association (TW), Pingtung Hospital (TW), National Defense Medical Center (TW), National Chengchi University (TW)
Good health and well-being
Openalex Percentile: Top 36%
Cardiovascular Syncope and Autonomic Disorders
DOIOpen Access PDFOpenAlex
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Zolpidem use and the risk of arrhythmia: A nationwide population-based cohort study in Taiwan — Chun‐An Cheng, Jiaying Shen, et al. · Journal of the Chinese Medical Association (2026) | TGRS Research Map | TGRS