Deep gray matter atrophy mediates the associations between glymphatic dysfunction and clinical disability in relapsing-remitting multiple sclerosis: a neuroimaging subgroup study
The RRMS subgroups based on the gradient classification of DGMV using structural MRI effectively distinguishes differences in glymphatic function and clinical disability. When DGM atrophy reaches a certain threshold, it partially mediates the relationship between glymphatic function and clinical disability.
Authors
- Jibin Cao (ORCID: https://orcid.org/0000-0003-0189-4467)
- M L Li
- Heng Zhang (ORCID: https://orcid.org/0000-0002-0103-2173)
- Ruisi Gong
- Jinlin Jiao
- yueluan jiang
- Lingling Cui
- Zixuan Song
- Feng Shi
- Ye Han
- Ziying Zhang
- Hefei Fu
Institutions
- First Hospital of China Medical University (CN)
- National Intelligence University (US)
- Siemens Healthcare (United States) (US)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-03-03
- DOI
- https://doi.org/10.3389/fimmu.2026.1758859
- Primary Topic
- Cerebrospinal fluid and hydrocephalus
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Beijing Institute of Technology
- China Medical University