Separable, symptom specific alterations in brain microstructure associated with early-stage Parkinson’s disease
In early-stage PD, motor and non-motor symptoms are mapped to anatomically distinct pathways, suggesting separable pathophysiological mechanisms. These findings further suggest that correlational tractography is appropriate to evaluate changes in structural connectivity in neurodegenerative diseases and, potentially, their therapeutic interventions.
Authors
- Aaron J. Suminski (ORCID: https://orcid.org/0000-0002-8793-5049)
- Alan B. McMillan (ORCID: https://orcid.org/0000-0003-4502-6522)
- Samuel A. Hurley (ORCID: https://orcid.org/0000-0003-3965-9649)
- Maureen Haebig (ORCID: https://orcid.org/0000-0002-4592-0076)
- Mikhail Moshchin
- Cuong P. Luu
- Catherine L. Gallagher
- Douglas C. Dean
- Andrew L. Alexander
Institutions
- University of Wisconsin–Madison (US)
- William S. Middleton Memorial Veterans Hospital (US)
- Neurological Surgery (US)
Publication Details
- Journal
- Frontiers in Neuroscience
- Published
- 2026-03-03
- DOI
- https://doi.org/10.3389/fnins.2026.1741159
- Primary Topic
- Advanced Neuroimaging Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- University of Wisconsin-Madison
- National Institutes of Health