Investigation of CLDN5 Gene 3′UTR rs10314 Polymorphism and Protein Levels in Children and Adolescents With ADHD: A Molecular and Clinical Correlation Study

This is the first study to assess both rs10314 and claudin-5 in ADHD and suggests that CLDN5 genetic variation and reduced claudin-5 expression may contribute to ADHD pathophysiology. Further studies are needed to confirm these findings and clarify their clinical implications. .

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Publication Details

Journal
Medical Principles and Practice
Published
2026-03-03
DOI
https://doi.org/10.1159/000551196
Primary Topic
Barrier Structure and Function Studies
Type
article
Field-Weighted Citation Impact
0.00

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article

Investigation of CLDN5 Gene 3′UTR rs10314 Polymorphism and Protein Levels in Children and Adolescents With ADHD: A Molecular and Clinical Correlation Study

Ahmet Osman Kılıç, Necati Uzun, İbrahim Kılınç, Emine Göktaş et al.
Medical Principles and Practice
Barrier Structure and Function Studies
article

Investigation of CLDN5 Gene 3′UTR rs10314 Polymorphism and Protein Levels in Children and Adolescents With ADHD: A Molecular and Clinical Correlation Study

Ahmet Osman Kılıç, Necati Uzun, İbrahim Kılınç, Emine Göktaş, Ayşegül Tuğba Hira Selen, Tuğba Deniz Kurnaz Demir
article en

Abstract

This is the first study to assess both rs10314 and claudin-5 in ADHD and suggests that CLDN5 genetic variation and reduced claudin-5 expression may contribute to ADHD pathophysiology. Further studies are needed to confirm these findings and clarify their clinical implications. .

Medical Principles and Practice
Necmettin Erbakan Üniversitesi
Reduced inequalities, Peace, Justice and strong institutions
Openalex Percentile: Top 49%
Barrier Structure and Function Studies
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