IGFBP-6 as a potential therapeutic target in musculoskeletal disorders

IGFBP-6 is expected to shift from a peripheral IGF modulator to a key node in musculoskeletal homeostasis as a result of the convergence of mechanical and extracellular signaling paradigms. A new avenue for focused intervention is defined by its junction with extracellular vesicle-mediated communication and IGF/SHH signaling. A new class of mechano-epigenetic modulators for fibrotic and articular diseases could be introduced by IGFBP-6-based therapies, which capitalize on its extracellular accessibility and domain-specific versatility.