Anti-CD7 fratricide-resistant chimeric antigen receptor T cells for relapsed/refractory acute myeloid leukemia
Autologous second-generation CD7-directed CAR T-cells, expressing an anti-CD7 protein expression blocker to prevent self-killing fratricide, were infused in three pediatric/young adult patients with relapsed/refractory CD7+ acute myeloid leukemia resulting in measurable residual disease negativity. The safety profile was favorable.
Authors
- Yunqin Lee
- Marco Becilli (ORCID: https://orcid.org/0000-0002-8874-4092)
- Biagio De Angelis (ORCID: https://orcid.org/0000-0002-7938-737X)
- Emilia Boccieri (ORCID: https://orcid.org/0009-0001-0675-8280)
- Laura Iaffaldano (ORCID: https://orcid.org/0000-0001-7673-5503)
- Dario Campana (ORCID: https://orcid.org/0000-0001-9980-3230)
- Stefano Di Cecca (ORCID: https://orcid.org/0000-0003-2595-9261)
- Federica Locatelli
- Chiara Rosignoli (ORCID: https://orcid.org/0000-0001-7429-1048)
- Maria Giuseppina Cefalo
- Pietro Merli
- Daria Pagliara
- Chiara Agrati
- Francesca Del Bufalo
- Soheil Meshinchi
- Valentina Bertaina
- Mattia Algeri
- Concetta Quintarelli
Institutions
- Fred Hutch Cancer Center (US)
- TauRx Pharmaceuticals (Singapore) (SG)
- National University Cancer Institute, Singapore (SG)
- Bambino Gesù Children's Hospital (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
Publication Details
- Journal
- Blood
- Published
- 2026-03-03
- DOI
- https://doi.org/10.1182/blood.2025032299
- Primary Topic
- CAR-T cell therapy research
- Type
- article
- Field-Weighted Citation Impact
- 0.00