From GPT-3.5 to GPT-5.2: a paired longitudinal evaluation of large language models in clinical neurology

The GPT-5.2 model demonstrated a significant performance increase compared with the previous model when presented with questions in clinical neurology. The performance increase was supported by high effect sizes, indicating potential clinical relevance. Model evolution was not homogeneous across subspecialties. Integrating it into clinical systems with strict control mechanisms may alleviate safety concerns.