A pre-emptive risk model for acute rejection in liver transplantation: an immunopharmacologic biomarker panel combining CD4+ T-cell profiling and tacrolimus exposure
We identify and validate a novel, clinically actionable immunopharmacologic biomarker panel for ACR. This model enables pre-emptive risk stratification by capturing the high-risk confluence of immune activation and subtherapeutic immunosuppression, paving the way for personalized immunotherapy in transplant recipients.
Authors
- Xian-Liang Li
- Q. Li
- Dongdong Han (ORCID: https://orcid.org/0000-0003-2273-3646)
- Han Li (ORCID: https://orcid.org/0000-0002-0286-3737)
- J Y Zhu
- Jun-Xi Zhang
- Qiang He
Institutions
- Capital Medical University (CN)
- China-Japan Friendship Hospital (CN)
- National Cancer Center (US)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-03-03
- DOI
- https://doi.org/10.3389/fimmu.2026.1760409
- Primary Topic
- Organ Transplantation Techniques and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 0.00