Phosphoproteomics uncovers a neuroimmune perspective on trigeminal neuralgia: sexually dimorphic regulatory networks linking calcium channels to the complement cascade

This study presents the first dual-omics atlas of the injured trigeminal ganglion. We identify a female-specific "Complement-Kininogen" axis and a conserved "MAPK-HSPB1" phosphorylation pathway as key drivers of TN. These findings provide a molecular explanation for the clinical gender bias and suggest that therapeutic strategies may need to be sex-stratified, with complement inhibition holding particular potential for female patients.