Extracellular vesicles in type 2 diabetes exhibit elevated miR-155 cargo and Annexin A1 concentration
Extracellular vesicles (EVs) are released by cells and are hypothesized to play important roles in inter-cellular communication while carrying signatures reflective of their origin cell. Our findings demonstrate that circulating EVs ~200-1000 nm in diameter are elevated in people living with T2D and exhibit distinct phenotypic and miRNA cargo profiles compared with healthy controls. These observations highlight the potential utility of circulating EVs as informative biomarkers of altered cellular states in T2D.
Authors
- Jonathan P. Little (ORCID: https://orcid.org/0000-0002-9796-2008)
- Isaac T. S. Li (ORCID: https://orcid.org/0000-0002-8450-5326)
- Christopher A. DeSouza (ORCID: https://orcid.org/0000-0001-9372-5083)
- Hashim Islam (ORCID: https://orcid.org/0000-0002-7145-0522)
- Alexandre Abílio de Souza Teixeira (ORCID: https://orcid.org/0000-0002-3099-7070)
- Jordan Boultbee
- Alexis Marcotte-Chénard
- Garett Jackson
Institutions
- Interior Health (CA)
- University of British Columbia (CA)
- University of Colorado Boulder (US)
- Integra (United States) (US)
- Institute of Biomedical Science (GB)
- University of British Columbia, Okanagan Campus (CA)
Publication Details
- Journal
- Life Sciences
- Published
- 2026-03-03
- DOI
- https://doi.org/10.1016/j.lfs.2026.124297
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00