CircEif3c/miR-96–5p/PHF20L1/MEOX2 axis in perivascular preadipocyte exosomes mediates fibroblast dysfunction and vascular remodeling
Our findings establish the PVPAC-derived exosomal circEif3c/miR-96-5p/PHF20L1/MEOX2 axis as a critical driver of hyperglycemia-induced vascular remodeling. Targeting this pathway presents a promising therapeutic strategy to combat diabetes-associated vascular pathology and its complications.
Authors
- Shuaiyong Zhang (ORCID: https://orcid.org/0000-0003-4655-2460)
- Qinghai Wang
- Shuxin Ge
- Jiayu Wang
- Peiqing Tian
- Yixuan Liu
- Ping Liu
- Ye Zhang (132223)
- Juan Zhang
- Peng Wang
Institutions
- Second Hospital of Shandong University (CN)
- Beijing Anzhen Hospital (CN)
- Second Hospital of Tianjin Medical University (CN)
- Qilu Hospital of Shandong University (CN)
- Tianjin Medical University (CN)
Publication Details
- Journal
- Non-coding RNA Research
- Published
- 2026-03-03
- DOI
- https://doi.org/10.1016/j.ncrna.2026.01.006
- Primary Topic
- Circular RNAs in diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00