HSV-2 gE2/gI2 are immune evasion molecules that bind IgG Fc to inhibit antibody-dependent cellular cytotoxicity
We conclude that antibodies to gC2/gD2/gE2 are targets of ADCC, that gE2/gI2 inhibits ADCC, and that an mAb that targets the gE2 IgG Fc binding domain can prevent this inhibition.
Authors
- Giulia Tebaldi
- Tina M. Cairns (ORCID: https://orcid.org/0000-0002-6112-6964)
- Kevin P. Egan (ORCID: https://orcid.org/0000-0002-6653-6110)
- Lauren M. Hook (ORCID: https://orcid.org/0000-0002-5540-2459)
- Tomas Bergström (ORCID: https://orcid.org/0000-0002-9257-6757)
- Kerry S. Campbell
- Harvey M. Friedman
- Gary H. Cohen
Institutions
- Fox Chase Cancer Center (US)
- Temple University Health System (US)
- University of Pennsylvania (US)
- University of Gothenburg (SE)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-03-03
- DOI
- https://doi.org/10.3389/fimmu.2026.1766722
- Primary Topic
- Herpesvirus Infections and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- University of Pennsylvania
- National Institutes of Health
- National Cancer Institute
- National Institute of Allergy and Infectious Diseases