Toward a visualized classifier for depression: characterization of hemodynamic patterns using time-domain fNIRS
The results suggest that individuals with MDD exhibit a higher change in HbO relative to their initial HbO levels, indicating a greater oxygenation demand to support prefrontal cortex activation during speech and memory processes. This pilot study utilizing multichannel TD-fNIRS technology on human subjects provides new insights into replicable physiological features, potentially enabling objective measurement of the underlying neuropathological symptoms of MDD.
Authors
- Gabrielle Wann Nii Tay (ORCID: https://orcid.org/0000-0001-6578-6049)
- Jie Li (ORCID: https://orcid.org/0000-0002-4366-7724)
- Zhifei Li
- Sisi Jing (ORCID: https://orcid.org/0000-0003-2879-7376)
- Nanguang Chen
- Kenneth De Sheng Tong
- Rachael Rui Qi Loh
- Jinyuan Wang
- E Du
- Cyrus Su Hui Ho
Institutions
- National University of Singapore (SG)
- Institute of Microelectronics (SG)
- Institute of Microelectronics (CN)
- National University Hospital (SG)
Publication Details
- Journal
- Frontiers in Psychiatry
- Published
- 2026-03-03
- DOI
- https://doi.org/10.3389/fpsyt.2026.1724011
- Primary Topic
- Optical Imaging and Spectroscopy Techniques
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National University of Singapore
- Government of Jiangsu Province
- Science and Technology Support Program of Jiangsu Province