Discovery of Pyridopyrazine Inverse Agonists Targeting G Protein-Coupled Receptor 6
This patent highlight describes the synthesis and assessment of a series of new inverse agonists targeting G protein-coupled receptor 6 (GPR6) based on pyridopyrazine analogs. It details their chemical synthesis, characterization, and biological activity assays.
Authors
- Steven H. Liang (ORCID: https://orcid.org/0000-0003-1413-6315)
- Y. Li
Institutions
- Georgia Institute of Technology (US)
- Emory University (US)
Publication Details
- Journal
- ACS Medicinal Chemistry Letters
- Published
- 2026-03-03
- DOI
- https://doi.org/10.1021/acsmedchemlett.6c00096
- Primary Topic
- Receptor Mechanisms and Signaling
- Type
- article
- Field-Weighted Citation Impact
- 0.00