Disruption of the angiopoietin-like system connects lipid homeostasis and hypothalamic dysfunction in ALS

These data provide a molecular mechanism linking peripheral lipid metabolism to the dysfunction of a specific hypothalamic circuit through the mediation of systemic ANGPTL-3 and -4. This finding constitutes a molecularly defined entry point to manipulate lipid metabolism in ALS.

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Publication Details

Journal
BMC Medicine
Published
2026-03-03
DOI
https://doi.org/10.1186/s12916-026-04749-4
Primary Topic
Amyotrophic Lateral Sclerosis Research
Type
article
Field-Weighted Citation Impact
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article

Disruption of the angiopoietin-like system connects lipid homeostasis and hypothalamic dysfunction in ALS

Veronika Klose, Diana Wiesner, Rami Saad, Özlem Parlak et al.
BMC Medicine
Amyotrophic Lateral Sclerosis Research
article

Disruption of the angiopoietin-like system connects lipid homeostasis and hypothalamic dysfunction in ALS

Veronika Klose, Diana Wiesner, Rami Saad, Özlem Parlak, Sruthi Sankari Krishnamurthy, Kornelia Günther, Luc Dupuis, Johannes Dorst, Francesco Roselli, Adriana Zardini Buzatto, Zeynep Elmas, Jochen Weishaupt, Caley Campkin, Liang Li (46069), Jan Kassubek, Hans-Peter Müller, Maximilian Wiesenfarth, Christine Herrmann, Albert Ludolph
article en

Abstract

These data provide a molecular mechanism linking peripheral lipid metabolism to the dysfunction of a specific hypothalamic circuit through the mediation of systemic ANGPTL-3 and -4. This finding constitutes a molecularly defined entry point to manipulate lipid metabolism in ALS.

BMC Medicine
University of Alberta (CA), Inserm (FR), University of Calgary (CA), Universität Ulm (DE), German Center for Neurodegenerative Diseases (DE), Helmholtz-Institute Ulm (DE), The Metabolomics Innovation Centre (CA), Technische Hochschule Ulm (DE), Université de Strasbourg (FR)
Gender equality
Openalex Percentile: Top 42%
Amyotrophic Lateral Sclerosis Research
DOIOpen Access PDFOpenAlex
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Disruption of the angiopoietin-like system connects lipid homeostasis and hypothalamic dysfunction in ALS — Veronika Klose, Diana Wiesner, et al. · BMC Medicine (2026) | TGRS Research Map | TGRS