Targeting CPSF73, the mRNA 3’ End Processing Endonuclease, Moves Cancer Cells Away from the Mesenchymal State
Our findings highlight APA-mediated 3' UTR lengthening as a coordinated mechanism that promotes EMT reversal and support CPSF73 inhibition or APA-targeting strategies as potential therapeutic approaches to suppress metastasis across multiple pathways.
Authors
- Claire Moore (ORCID: https://orcid.org/0000-0002-1883-9459)
- Ehsan Ranaei Pirmardan (ORCID: https://orcid.org/0000-0002-6848-5839)
- Salwa Mohd Mostafa
- Luyang Wang (ORCID: https://orcid.org/0000-0001-7825-0518)
- Bin Tian
- Huiyun Liu
- Marzieh Naseri
Institutions
- The Wistar Institute (US)
- Tufts University (US)
Publication Details
- Journal
- bioRxiv (Cold Spring Harbor Laboratory)
- Published
- 2026-03-03
- DOI
- https://doi.org/10.64898/2026.03.01.708894
- Primary Topic
- RNA Research and Splicing
- Type
- article
- Field-Weighted Citation Impact
- 0.00