Post-traumatic Hypertrophic Olivary Degeneration with Palatal Myoclonus–A Case Report

This is a case report of a 7-year-old boy with a medical history of a motor vehicle accident (MVA) 2 years previously. Two years post-MVA, he developed quivering and twitching of the right side of his lip, palate, and neck. Multiple antiseizure medications were attempted with no effect. However, carbamazepine was started with marked improvement. The most recent brain magnetic resonance imaging showed findings suggestive of hypertrophic olivary degeneration (HOD). Electroencephalography captured the abnormal facial twitching with audible palatal clicking, but was not associated with electrographic changes. This case demonstrates the anatomic importance of the Guillain-Mollaret triangle, as traumatic disruption of this pathway resulted in palatal myoclonus. HOD occurring due to trauma is an incredibly rare etiology, with only 1 other case reported in the literature in a 27-year-old man, with no previous reports of posttraumatic HOD occurring in an individual under 18 discovered during our literature review.

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Publication Details

Journal
Journal of Child Neurology
Published
2026-03-03
DOI
https://doi.org/10.1177/08830738261417414
Primary Topic
Glycogen Storage Diseases and Myoclonus
Type
article
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article

Post-traumatic Hypertrophic Olivary Degeneration with Palatal Myoclonus–A Case Report

Suad Khalil, Katherine Bailey, Jacob T Hanson
Journal of Child Neurology
Glycogen Storage Diseases and Myoclonus
article

Post-traumatic Hypertrophic Olivary Degeneration with Palatal Myoclonus–A Case Report

Suad Khalil, Katherine Bailey, Jacob T Hanson
article en

Abstract

This is a case report of a 7-year-old boy with a medical history of a motor vehicle accident (MVA) 2 years previously. Two years post-MVA, he developed quivering and twitching of the right side of his lip, palate, and neck. Multiple antiseizure medications were attempted with no effect. However, carbamazepine was started with marked improvement. The most recent brain magnetic resonance imaging showed findings suggestive of hypertrophic olivary degeneration (HOD). Electroencephalography captured the abnormal facial twitching with audible palatal clicking, but was not associated with electrographic changes. This case demonstrates the anatomic importance of the Guillain-Mollaret triangle, as traumatic disruption of this pathway resulted in palatal myoclonus. HOD occurring due to trauma is an incredibly rare etiology, with only 1 other case reported in the literature in a 27-year-old man, with no previous reports of posttraumatic HOD occurring in an individual under 18 discovered during our literature review.

Journal of Child Neurology
Rocky Vista University (US), Michigan State University (US)
Good health and well-being
Openalex Percentile: Top 36%
Glycogen Storage Diseases and Myoclonus
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Post-traumatic Hypertrophic Olivary Degeneration with Palatal Myoclonus–A Case Report — Suad Khalil, Katherine Bailey, et al. · Journal of Child Neurology (2026) | TGRS Research Map | TGRS