Lactate‐Induced <scp>H3K18</scp> Lactylation by p300 Promotes Odontogenic Differentiation of Human Dental Pulp Stem Cells via <scp>WNT5A</scp> /Ca <sup>2+</sup> Signalling Pathway: A Laboratory Investigation
The lactate-driven mechanism acts through the p300-mediated H3K18la-WNT5A/Ca<sup>2+</sup> signalling axis to promote the odontogenic differentiation of hDPSCs. The crosstalk between metabolism, epigenetic modifications and signalling pathways of hDPSCs might offer novel strategies for dental pulp regeneration.
Authors
- Shengyan Yang (ORCID: https://orcid.org/0000-0003-1211-7495)
- Waruna Lakmal Dissanayaka (ORCID: https://orcid.org/0000-0002-3621-4866)
- B Chen
- Yiwen Zhang (ORCID: https://orcid.org/0000-0002-7304-9820)
- XU Qiong (ORCID: https://orcid.org/0000-0001-8065-8766)
- Yongjie Cai (ORCID: https://orcid.org/0000-0003-2119-4134)
- Xiaoting Peng
- Yiqing Zhao
Institutions
- Peking University Shenzhen Hospital (CN)
- Stomatology Hospital (CN)
- University of Hong Kong (HK)
Publication Details
- Journal
- International Endodontic Journal
- Published
- 2026-03-02
- DOI
- https://doi.org/10.1111/iej.70130
- Primary Topic
- Bone and Dental Protein Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00