Phage–antibiotic synergy restores β-lactam efficacy in MDR Klebsiella quasipneumoniae biofilms and suppresses resistance
Our findings highlight a precision-guided strategy with translational potential for device-associated infections, providing a mechanistic and methodological foundation for optimizing PAS-based therapies.
Authors
- Kamran A. Mirza (ORCID: https://orcid.org/0009-0008-1943-768X)
- Tinatini Tchatchiashvili (ORCID: https://orcid.org/0000-0002-0281-1208)
- Ralf Ehricht (ORCID: https://orcid.org/0000-0002-6612-0043)
- Mara Lohde (ORCID: https://orcid.org/0009-0009-1718-7231)
- Ekaterine Gabashvili
- Mathias W. Pletz
- Christian Brandt
- Oliwia Makarewicz
Institutions
- Leibniz Institute of Photonic Technology (DE)
- Jena University Hospital (DE)
- InfectoGnostics Research Campus Jena (DE)
- Friedrich Schiller University Jena (DE)
Publication Details
- Journal
- Journal of Biomedical Science
- Published
- 2026-03-04
- DOI
- https://doi.org/10.1186/s12929-026-01218-1
- Primary Topic
- Bacteriophages and microbial interactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Bundesministerium für Bildung und Forschung