Small Extracellular Vesicle External Surface Adiponectin-Mediated Adipocytes/Cardiomyocytes Communication in Diabetic Ischemic Heart Failure
Our study reveals that APN is enriched on the ADp-derived external surface of sEVs and is biologically active, playing a critical role in ADp-cardiomyocyte communication. Diabetes disrupts this communication by enhancing GRK2-mediated AdipoR1 phosphorylation, impairing sEV signaling, and exacerbating IHF. These findings provide new insights into the pathophysiology and therapy of IHF in diabetes.
Authors
- B. Mongil Lopez (ORCID: https://orcid.org/0000-0001-6309-4575)
- Z Zhang
- Di Zhu (ORCID: https://orcid.org/0000-0001-8046-0709)
- Jianli Zhao (ORCID: https://orcid.org/0000-0003-4662-2940)
- Yajing Wang (ORCID: https://orcid.org/0000-0002-6766-2549)
- Demin Liu
- Peng Yao
- Guoqiang Gu
- Xinliang Ma
- Zhijun Meng
- Theodore A. Christopher
- Lu Gan
- Caihong Liu
Institutions
- Thomas Jefferson University (US)
- University of Alabama at Birmingham (US)
Publication Details
- Journal
- Circulation
- Published
- 2026-03-02
- DOI
- https://doi.org/10.1161/circulationaha.125.076372
- Primary Topic
- Adipokines, Inflammation, and Metabolic Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00