DNA methylation is associated with von Willebrand factor and coagulation factor VIII plasma levels: the atherosclerosis risk in communities study

We identified novel epigenetic associations with VWF and FVIII levels at the NBEAL2 and B3GALT4 loci. NBEAL2 is critical for the biosynthesis of platelet alpha granules, which store proteins that enable platelet adhesion initiation, including VWF while B3GALT4 is involved in glycosylation of glycoproteins like VWF and FVIII.

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Publication Details

Journal
Clinical Epigenetics
Published
2026-03-02
DOI
https://doi.org/10.1186/s13148-025-02028-2
Primary Topic
Platelet Disorders and Treatments
Type
article
Field-Weighted Citation Impact
0.00
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article

DNA methylation is associated with von Willebrand factor and coagulation factor VIII plasma levels: the atherosclerosis risk in communities study

N L Smith, Jan Bressler, Paul S. de Vries, Myriam Fornage et al.
Clinical Epigenetics
Platelet Disorders and Treatments
article

DNA methylation is associated with von Willebrand factor and coagulation factor VIII plasma levels: the atherosclerosis risk in communities study

N L Smith, Jan Bressler, Paul S. de Vries, Myriam Fornage, Alanna C. Morrison, Eric Boerwinkle, Julie Hahn
article en

Abstract

We identified novel epigenetic associations with VWF and FVIII levels at the NBEAL2 and B3GALT4 loci. NBEAL2 is critical for the biosynthesis of platelet alpha granules, which store proteins that enable platelet adhesion initiation, including VWF while B3GALT4 is involved in glycosylation of glycoproteins like VWF and FVIII.

Clinical Epigenetics
University of Washington (US), The University of Texas Health Science Center (US), Seattle University (US), The University of Texas Health Science Center at Houston (US)
Openalex Percentile: Top 36%
Platelet Disorders and Treatments
DOIOpen Access PDFOpenAlex
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