Role of urinary leukocytes in the risk stratification of prostate cancer using nonlinear stacking learning strategy: a bi-cohort diagnostic study

Within a stacking ensemble-based risk stratification framework primarily optimized for predictive performance, urinary leukocytes provide a clinically meaningful auxiliary signal that improves discrimination and net benefit in specific PSA-defined subgroups. These findings support the use of UL as a complementary inflammation-related marker in PCa risk assessment, while interpretability is best understood at the level of base learners and original clinical features rather than the full ensemble model.

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Publication Details

Journal
Frontiers in Oncology
Published
2026-03-02
DOI
https://doi.org/10.3389/fonc.2026.1762494
Primary Topic
Prostate Cancer Diagnosis and Treatment
Type
article
Field-Weighted Citation Impact
0.00

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article

Role of urinary leukocytes in the risk stratification of prostate cancer using nonlinear stacking learning strategy: a bi-cohort diagnostic study

Chunguang Yang, Hao Zhu, Mengzhe Cheng, Zhenchun Ran et al.
Frontiers in Oncology
Prostate Cancer Diagnosis and Treatment
article

Role of urinary leukocytes in the risk stratification of prostate cancer using nonlinear stacking learning strategy: a bi-cohort diagnostic study

Chunguang Yang, Hao Zhu, Mengzhe Cheng, Zhenchun Ran, Shou Xia, Xinglong Wu
article en

Abstract

Within a stacking ensemble-based risk stratification framework primarily optimized for predictive performance, urinary leukocytes provide a clinically meaningful auxiliary signal that improves discrimination and net benefit in specific PSA-defined subgroups. These findings support the use of UL as a complementary inflammation-related marker in PCa risk assessment, while interpretability is best understood at the level of base learners and original clinical features rather than the full ensemble model.

Frontiers in OncologyVol. 16
Xi'an Polytechnic University (CN), Cohu (United States) (US), Hubei University of Science and Technology (CN), Tongji Hospital (CN), Artificial Intelligence in Medicine (Canada) (CA), Huazhong University of Science and Technology (CN), Wuhan Institute of Technology (CN)
Huazhong University of Science and Technology, Tongji University, Tongji Medical College, Huazhong University of Science and Technology
Openalex Percentile: Top 36%
Prostate Cancer Diagnosis and Treatment
DOIOpen Access PDFOpenAlex
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Role of urinary leukocytes in the risk stratification of prostate cancer using nonlinear stacking learning strategy: a bi-cohort diagnostic study — Chunguang Yang, Hao Zhu, et al. · Frontiers in Oncology (2026) | TGRS Research Map | TGRS