Occupational silica exposure drives systemic immune dysregulation and tumor microenvironment susceptibility: evidence from a real-world study
Occupational silica exposure induces macrophage-driven inflammatory signaling that promotes early CEA elevation and TME remodeling. Integrating machine learning with experimental and multi-omics validation provides a translational framework for identifying exposure-responsive biomarkers and immune-related cancer risk in occupational settings.
Authors
- Zaitian Zhang (ORCID: https://orcid.org/0000-0003-3049-3128)
- Han Hao (ORCID: https://orcid.org/0000-0001-7730-561X)
- Jingyi Zhao (ORCID: https://orcid.org/0000-0002-3125-2716)
- Q. Luo
- Hui Zhang
- Liu Baishan
Institutions
- North China University of Science and Technology (CN)
- First Affiliated Hospital of Hunan University of Traditional Chinese Medicine (CN)
- Chengde Medical University (CN)
- First Affiliated Hospital of University of South China (CN)
- Chongqing Jiulongpo People's Hospital (CN)
- Children's Hospital of Chongqing Medical University (CN)
- Chongqing Medical University (CN)
- University of South China (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-03-02
- DOI
- https://doi.org/10.3389/fimmu.2026.1775236
- Primary Topic
- Occupational and environmental lung diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Chengde Medical University