Aberrant oxidative metabolism selects for <i>TET2</i> -deficient hematopoietic stem and progenitor cells
This study identifies oxidative metabolism as a critical driver of selection for <i>TET2</i> -deficient HSPC in clonal hematopoiesis (CH). It also demonstrates that cellular redox state is a vulnerability that impairs their fitness. These insights establish targetable metabolic pathway(s) that could be exploited in the setting of <i>TET2</i> mutant CH.
Authors
- Wolfgang E. Schleicher (ORCID: https://orcid.org/0000-0001-6054-3435)
- Tracy N. Young (ORCID: https://orcid.org/0009-0002-6635-3303)
- Katia E. Niño (ORCID: https://orcid.org/0000-0002-6576-6002)
- Eric M. Pietras (ORCID: https://orcid.org/0000-0002-7339-8828)
- Devyani Sharma (ORCID: https://orcid.org/0000-0002-2210-5888)
- Keisuke Ito (ORCID: https://orcid.org/0000-0002-6702-9735)
- Mohsen Hosseini (ORCID: https://orcid.org/0000-0002-1686-8512)
- Angelica Varesi (ORCID: https://orcid.org/0000-0002-1246-2320)
- Etienne Danis (ORCID: https://orcid.org/0000-0002-5651-8111)
- Meelad M. Dawlaty (ORCID: https://orcid.org/0000-0003-3121-2500)
- Steven M. Chan (ORCID: https://orcid.org/0000-0002-4354-0731)
- A Gray
- S. Colla
- Stephanie Zhi-Juan Xie (ORCID: https://orcid.org/0000-0002-0284-494X)
- Vera Ademà (ORCID: https://orcid.org/0000-0001-6051-4378)
- Feyiang Ma (ORCID: https://orcid.org/0000-0002-6260-0787)
- Courtney M Cowan
- Steven Moreira (ORCID: https://orcid.org/0000-0003-3350-2093)
- Sierra N. Bennett
- Lin Tan (ORCID: https://orcid.org/0000-0001-8440-5643)
- Curtis A. Anderson (ORCID: https://orcid.org/0009-0002-1572-9091)
- Angelo D'Alessandro
- Sweta B Patel
- Julie A. Reisz
- Marie-Dominique Filippi
- Irene Ganan-Gomez
- Gang Huang
- Guillermo Garcia-Manero
- Kelly Chien
- Hsin-Ying Lin
Institutions
- Cincinnati Children's Hospital Medical Center (US)
- Albert Einstein College of Medicine (US)
- University Health Network (CA)
- The University of Texas MD Anderson Cancer Center (US)
- University of Toronto (CA)
- Princess Margaret Cancer Centre (CA)
- University of Colorado Cancer Center (US)
- The University of Texas at San Antonio (US)
- University of Colorado Anschutz Medical Campus (US)
- University of Colorado Denver (US)
Publication Details
- Journal
- bioRxiv (Cold Spring Harbor Laboratory)
- Published
- 2026-03-02
- DOI
- https://doi.org/10.64898/2026.02.28.707294
- Primary Topic
- Acute Myeloid Leukemia Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00