B and T cell responses to pre-erythrocytic R21/Matrix-M and blood-stage RH5.1/Matrix-M malaria vaccines in endemic settings
While our conclusions would be strengthened by further analyses in larger clinical trials, our data indicate that age, adjuvant dose, vaccine dose, and timing of final booster vaccination impact antigen-specific cellular responses to malaria vaccines and could thus inform the development of next-generation multi-stage malaria vaccination strategies.
Authors
- Wilmina F. Kalinga
- Domtila Kimani (ORCID: https://orcid.org/0000-0001-6534-5980)
- Carolyn M. Nielsen (ORCID: https://orcid.org/0000-0002-9033-1318)
- Ivanny M. Mtaka
- Caroline K Bundi (ORCID: https://orcid.org/0000-0003-2055-971X)
- Rodney Ogwang (ORCID: https://orcid.org/0000-0002-6125-7956)
- Duncan Bellamy (ORCID: https://orcid.org/0000-0003-3614-0032)
- Jordan R. Barrett (ORCID: https://orcid.org/0000-0003-0746-1945)
- Ally Olotu (ORCID: https://orcid.org/0000-0001-6696-1937)
- Olivia Muñoz (ORCID: https://orcid.org/0000-0002-1745-2156)
- Lisa Stockdale (ORCID: https://orcid.org/0000-0002-2576-8783)
- S. J. Draper
- Angela M. Minassian (ORCID: https://orcid.org/0000-0001-7832-9824)
- Sarah E. Silk (ORCID: https://orcid.org/0000-0003-0563-4814)
- Kirsty McHugh (ORCID: https://orcid.org/0000-0002-5411-7883)
- Elizabeth Kibwana
- Lydia Nyamako
- Kelvias Keter
- Katie J Ewer
- Adrian V. S. Hill
- Melissa C. Kapulu
- Philip Bejon
Institutions
- Ifakara Health Institute (TZ)
- Angkor Hospital for Children (KH)
- Kenya Medical Research Institute (KE)
- National Institute for Health and Care Research (GB)
- University of Oxford (GB)
- Jenner Institute (GB)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-03-02
- DOI
- https://doi.org/10.3389/fimmu.2026.1743327
- Primary Topic
- Malaria Research and Control
- Type
- article
- Field-Weighted Citation Impact
- 0.00