Follicular fluid from women with polycystic ovary syndrome induces granulosa cells metabolic dysfunction that is exacerbated by obesity
Granulosa cells depict metabolic dysregulation, with reduced glycolytic activity and impaired mitochondrial function, when exposed to FF from women with PCOS, which is further exacerbated in the presence of obesity. These findings from a pilot hypothesis-generating study suggest that the intrafollicular environment may be associated with granulosa cell metabolic disturbances, which warrant mechanistic studies to establish causality and elucidate the downstream consequences for follicular maturation and ovulatory function.
Authors
- David F. Carrageta (ORCID: https://orcid.org/0000-0002-0546-3480)
- Raquel L. Bernardino (ORCID: https://orcid.org/0000-0002-1941-6634)
- Emídio Vale-Fernandes (ORCID: https://orcid.org/0000-0002-2967-2666)
- Carla Leal (ORCID: https://orcid.org/0000-0002-6881-724X)
- M. Monteiro
- Raquel Brandão
- Mafalda V. Moreira
- Duarte Pignatelli
- Anna Ptak
- Daniela Sousa
- Bárbara Guerra-Carvalho
Institutions
- Universidade do Porto (PT)
- Hospital de São João (PT)
- Translational Research in Oncology (FR)
- Hospital de Santo António (PT)
- Rede de Química e Tecnologia (PT)
- Institute of Zoology of the Slovak Academy of Sciences (SK)
- i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto (PT)
- University of Aveiro (PT)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2026-03-02
- DOI
- https://doi.org/10.3389/fendo.2026.1783780
- Primary Topic
- Ovarian function and disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00