Is current guidance for cloxacillin prophylaxis dosages in hip and knee arthroplasty adequate? Evidence from a prospective Swedish cohort
Current cloxacillin dosing in hip and knee arthroplasty surgery results in a risk for subtherapeutic levels in patients with high body weight and preserved renal function. Therefore, dosing guidelines for cloxacillin prophylaxis in arthroplasty should be reviewed.
Authors
- Christian G. Giske (ORCID: https://orcid.org/0000-0003-4327-6122)
- Erik Eliasson (ORCID: https://orcid.org/0000-0002-4707-4256)
- Sari Ponzer (ORCID: https://orcid.org/0000-0003-0573-8509)
- Katja Wallander (ORCID: https://orcid.org/0000-0003-0437-4854)
- Eriksen Jaran
- Bo Söderquist (ORCID: https://orcid.org/0000-0001-5939-2932)
- Gustaf Beijer
Institutions
- Karolinska University Hospital (SE)
- Örebro University (SE)
- Karolinska Institutet (SE)
- Stockholm South General Hospital (SE)
Publication Details
- Journal
- Journal of Antimicrobial Chemotherapy
- Published
- 2026-02-02
- DOI
- https://doi.org/10.1093/jac/dkag067
- Primary Topic
- Orthopedic Infections and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00