Anti-angiotensin II type 1 receptor autoantibodies of IgG3 subclass outperform total anti-AT1R IgG1-IgG4 levels in predicting transplanted kidney antibody-mediated rejection
AT1R antibodies of IgG3 subclass outperform total AT1R levels in predicting AMR, revealing pathogenic antibody patterns that are not detectable through global IgG quantitation. Subclass profiling may contribute to more precise AMR risk assessment, but longitudinal and multicentre validation studies with standardized subclass-specific assays are needed to confirm these findings. Although AT1R IgG3 levels were significantly correlated with AMR, the magnitude of these associations is insufficient to support their use as an independent diagnostic marker and may only serve as a complementary AMR marker.
Authors
- Dariusz Janczak (ORCID: https://orcid.org/0000-0003-4671-9128)
- Agnieszka Hałoń (ORCID: https://orcid.org/0000-0003-4240-7899)
- Patryk Jerzak (ORCID: https://orcid.org/0000-0001-9004-184X)
- Karolina Marek-Bukowiec (ORCID: https://orcid.org/0000-0003-0606-9466)
- Guido Moll (ORCID: https://orcid.org/0000-0001-6173-5957)
- Jakub Mizera (ORCID: https://orcid.org/0000-0002-8112-9257)
- Rusan Catar (ORCID: https://orcid.org/0000-0002-7000-7860)
- Piotr Donizy (ORCID: https://orcid.org/0000-0002-8729-6216)
- Karolina Władyczak
- Mirosław Banasik
- M Rakowski
Institutions
- Wroclaw Medical University (PL)
- Humboldt-Universität zu Berlin (DE)
- Berlin Institute of Health at Charité - Universitätsmedizin Berlin (DE)
- Cell Medica (Switzerland) (CH)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-03-02
- DOI
- https://doi.org/10.3389/fimmu.2026.1776113
- Primary Topic
- Renal Transplantation Outcomes and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- European Commission
- Deutsche Forschungsgemeinschaft
- Bundesministerium für Bildung und Forschung
- Uniwersytet Medyczny im. Piastów Slaskich we Wroclawiu
- Berlin-Brandenburg School for Regenerative Therapies