Total Gleason Pattern 4 Length Outperforms Grade Group and Clinical Models in Predicting Oncologic Outcomes in Grade Group 2-4 Prostate Cancer
In Grade group 2-4 prostate cancer, total Gleason pattern 4 length for the case is a stronger predictor of adverse pathologic stage and biochemical recurrence than Grade group and other standard clinical variables. Further research is warranted to determine the optimal method for quantifying pattern 4 before incorporation into risk stratification algorithms.
Authors
- Melissa J. Assel (ORCID: https://orcid.org/0009-0004-6344-9371)
- Nate Aiken
- Samson W Fine
- Reuter Ve
- Behfar Ehdaie
- Nicole Liso
- Andrew J Vickers
- Sean A. Fletcher
- Nicholas Alexander Pickersgill
Institutions
- Memorial Sloan Kettering Cancer Center (US)
Publication Details
- Journal
- medRxiv
- Published
- 2026-03-02
- DOI
- https://doi.org/10.64898/2026.02.27.26347289
- Primary Topic
- Prostate Cancer Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Memorial Sloan-Kettering Cancer Center
- OPKO Health
- National Institutes of Health
- Sidney Kimmel Center for Prostate and Urologic Cancers
- National Cancer Institute