The enhanced osteogenic differentiation of human periodontal ligament stem cells and M2 polarization of macrophages may be mediated by EphB4/ephrinB2 signaling pathway: a study of their direct co-culture

Our data suggest a potential mediatory role for the EphB4/ephrinB2 pathway in the osteogenic differentiation of hPDLSCs and the polarization of M2-Mφ within the co-culture system. Its regulatory effect on the osteogenic differentiation of hPDLSCs may involve the STAT3 signaling pathway.

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Publication Details

Journal
Stem Cell Research & Therapy
Published
2026-03-02
DOI
https://doi.org/10.1186/s13287-026-04946-1
Primary Topic
Axon Guidance and Neuronal Signaling
Type
article
Field-Weighted Citation Impact
0.00
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article

The enhanced osteogenic differentiation of human periodontal ligament stem cells and M2 polarization of macrophages may be mediated by EphB4/ephrinB2 signaling pathway: a study of their direct co-culture

Yijun Luan, Qiuyue Yin, Aimei Song, Jiling Qiu et al.
Stem Cell Research & Therapy
Axon Guidance and Neuronal Signaling
article

The enhanced osteogenic differentiation of human periodontal ligament stem cells and M2 polarization of macrophages may be mediated by EphB4/ephrinB2 signaling pathway: a study of their direct co-culture

Yijun Luan, Qiuyue Yin, Aimei Song, Jiling Qiu, Hailong Liu, Hui Song, Xiaoqian Yang, Huaze Ren
article en

Abstract

Our data suggest a potential mediatory role for the EphB4/ephrinB2 pathway in the osteogenic differentiation of hPDLSCs and the polarization of M2-Mφ within the co-culture system. Its regulatory effect on the osteogenic differentiation of hPDLSCs may involve the STAT3 signaling pathway.

Stem Cell Research & Therapy
Weifang Medical University (CN), Shandong University (CN), Weifang People's Hospital (CN), Zhongshan Hospital of Xiamen University (CN), Shandong Provincial QianFoShan Hospital (CN), Qilu Hospital of Shandong University (CN), Shandong First Medical University (CN)
Openalex Percentile: Top 37%
Axon Guidance and Neuronal Signaling
DOIOpen Access PDFOpenAlex
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The enhanced osteogenic differentiation of human periodontal ligament stem cells and M2 polarization of macrophages may be mediated by EphB4/ephrinB2 signaling pathway: a study of their direct co-culture — Yijun Luan, Qiuyue Yin, et al. · Stem Cell Research & Therapy (2026) | TGRS Research Map | TGRS