Primary pancreatic Burkitt’s lymphoma presenting as gastric outlet obstruction

Abstract Lymphomas are a diverse group of malignancies originating from lymphoid cells, which can affect any organ system and present with a wide variety of symptoms. Non-Hodgkin’s lymphoma accounts for the majority of lymphomas and can involve extranodal sites in up to 50% of cases. Primary pancreatic lymphomas are rare, with Burkitt’s lymphoma (BL) being an exceptionally uncommon variant. We report the case of a 16-year-old male who presented with symptoms of gastric outlet obstruction, abdominal discomfort, and weight loss. Diagnostic imaging revealed a diffusely enlarged pancreas causing duodenal compression, and histopathological examination confirmed a diagnosis of primary pancreatic BL. The patient was treated with a chemotherapy regimen and a feeding jejunostomy to maintain nutrition. Following treatment, he showed significant clinical improvement and remained asymptomatic at 6 months. This case underscores the rarity of primary pancreatic BL and highlights the importance of considering it in differential diagnoses for gastric outlet obstruction, particularly in younger patients. Early diagnosis and treatment are crucial for improving outcomes. The following core competencies are addressed in this article: Medical knowledge, patient care, practice based learning and diagnostic reasoning..