Mechanistic insights into B-cell activation and autoreactivity regulation in active SLE and remission

The signatures identified help define the "immunological reset" state in patients with SLE-R. We also identified pathways, such as type I IFN, TNFR2, FcγRIIb, IL-4/STAT6 as potential targets for maintaining remission.

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Publication Details

Journal
bioRxiv (Cold Spring Harbor Laboratory)
Published
2026-03-02
DOI
https://doi.org/10.64898/2026.02.27.708589
Primary Topic
Systemic Lupus Erythematosus Research
Type
article
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article

Mechanistic insights into B-cell activation and autoreactivity regulation in active SLE and remission

M Mackay, Betty Diamond, Rita Pozovskiy, Yemil Atisha-Fregoso
bioRxiv (Cold Spring Harbor Laboratory)
Systemic Lupus Erythematosus Research
article

Mechanistic insights into B-cell activation and autoreactivity regulation in active SLE and remission

M Mackay, Betty Diamond, Rita Pozovskiy, Yemil Atisha-Fregoso
article en

Abstract

The signatures identified help define the "immunological reset" state in patients with SLE-R. We also identified pathways, such as type I IFN, TNFR2, FcγRIIb, IL-4/STAT6 as potential targets for maintaining remission.

bioRxiv (Cold Spring Harbor Laboratory)
Feinstein Institute for Medical Research (US), Hofstra University (US)
Openalex Percentile: Top 37%
Systemic Lupus Erythematosus Research
DOIOpen Access PDFOpenAlex
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Mechanistic insights into B-cell activation and autoreactivity regulation in active SLE and remission — M Mackay, Betty Diamond, et al. · bioRxiv (Cold Spring Harbor Laboratory) (2026) | TGRS Research Map | TGRS