Interaction between NKG2D and its ligands MICA/B activates the DAP12/SYK/p53/p21 axis to drive pulmonary fibrosis
This study proposes that the NKG2D-DAP12-SYK-p53-p21 axis may represent a novel pathogenic pathway in PF, potentially linking immune dysregulation to cellular senescence. Therapeutic targeting of NKG2D could thus hold promise for the concurrent modulation of immune-fibrotic crosstalk and fibrotic progression, which might offer a new strategic direction for PF management.
Authors
- Jinlian He (ORCID: https://orcid.org/0000-0002-9961-2482)
- Qingming Ke
- Ruimin Tian (ORCID: https://orcid.org/0000-0003-2740-5510)
- Hong Ren
- Qiuzhu Chen
- Hudan Pan
- Caiping Zhao
- Liang Liu
Institutions
- Guangzhou University of Chinese Medicine (CN)
- Hennepin County (US)
- Guangzhou Experimental Station (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-03-02
- DOI
- https://doi.org/10.3389/fimmu.2026.1770733
- Primary Topic
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00