DENTAL COMPONENTS OF ENDOGENOUS INTOXICATION IN THE PATHOGENESIS AND TREATMENT OF GENERALIZED PАRODONTAL DISEASES IN PATIENTS WITH EATING DISORDERS

Abstract. Violation of the structural organization of cell membranes, in particular under the influence of free radical oxidation processes, determines the main pathophysiological and clinical manifestations and decompensation of the pathological process in the periodontium. Prognostic for the assessment of endotoxicosis is clinical and biochemical monitoring of antioxidant system (AOS) parameters, in particular medium-weight peptides in patients with eating disorders. Aim: to determine some dental markers of endogenous intoxication in patients with generalized parodontal diseases with eating disorders. Materials and Methods. The main group was 60 patients (aged 19–44 years) with GPD (generalized pаrodontitis (GP), initial-II stage, chronic course) with ED. The comparison group included 45 patients of similar age, equal in gender, with GPP without eating disorders and 35 people with ED without GPD, as well as 30 practically healthy people with clinically intact periodontium. Clinical-radiological, laboratory (determination of peptides of average mass), as well as statistical research methods were used. Research Results. In patients of the main group the concentration of middle molecules weight determined in blood serum at a wavelength of 254 nm (MMW254) (corresponding chain amino acids), was equal to 0.067 ± 0.002 (opt. units) in contrast to the indicator in the comparative groups, which was set at the level of 0.060±0.001 (opt. units) and 0.076 ± 0.002 (opt. units) respectively. In the control group, this indicator was 0.053 ± 0.001 (opt. units). In patients of the main group, the MMW280 indicator was equal to 0.064 ± 0.001 (opt. units) in contrast to the indicator in the comparative groups, which was set at the level of 0.059 ± 0.001 (opt. units) and 0.082 ± 0.001 (opt. units) respectively. In the control group, this indicator was 0.049 ± 0.001 (opt. units). Therefore, the maximum accumulation of middle molecules weight in the oral fluid in patients with combined pathology – GP and ED is evidence of parallel processes of potentiation of metabolic disorders characteristic of these pathological conditions. Conclusions. The obtained data confirm the presence of a pronounced interdependence between the level of endogenous intoxication and the severity of generalized periodontitis in patients with eating disorders, which indicates the need to include in the complex treatment of detoxification agents – both systemic and local, in combination with professional and individual oral hygiene.