Genome-wide DNA methylation analysis of pediatric medulloblastomas from a Brazilian cohort: an exploratory study
This exploratory study highlights the importance of validating DNA methylation-based biomarkers across diverse populations. The global methylation patterns observed in this Brazilian cohort were largely consistent with those reported in large international reference datasets, while also underscoring the value of population-aware analyses in expanding the diversity of epigenomic reference data.
Authors
- Sebastián Morales (ORCID: https://orcid.org/0000-0001-8234-6299)
- Antônio Duarte Pagano
- William Borges Domingues (ORCID: https://orcid.org/0000-0002-4351-2271)
- Hadassa Gabriela Ortiz
- Ciliana Rechenmacher (ORCID: https://orcid.org/0000-0002-1321-5807)
- Vinícius Farias Campos (ORCID: https://orcid.org/0000-0003-2119-293X)
- Ricardo Fernández‐Ramires (ORCID: https://orcid.org/0000-0002-6974-2593)
- Mariana Bohns Michalowski (ORCID: https://orcid.org/0000-0002-9482-0776)
- Frederico Schmitt Kremer
- Sidnei Epelman
- Antônio Fernando da Purificação Júnior
Institutions
- Universidad Mayor (CL)
- Universidade Federal de Pelotas (BR)
- Fundación Chile (CL)
- Hospital de Clínicas de Porto Alegre (BR)
- Hospital Santa Marcelina (BR)
Publication Details
- Journal
- Clinical & Translational Oncology
- Published
- 2026-03-02
- DOI
- https://doi.org/10.1007/s12094-026-04304-w
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 0.00