Precision diagnosis and therapy for pediatric central nervous system tumors: consensus from the Brazilian Society of Pediatric Oncology (SOBOPE)
Precision medicine has reshaped the classification and management of pediatric central nervous system tumors, enabling more accurate diagnoses and targeted therapies. However, access to molecular diagnostics and precision treatments remains uneven in many low- and middle-income countries, including Brazil. To address this gap, the Brazilian Society of Pediatric Oncology (SOBOPE) convened a national expert panel to develop consensus recommendations adapted to the Brazilian healthcare context. Using a structured literature overview and a modified Delphi process involving pediatric oncologists, neuropathologists, and laboratory medicine specialists, the panel proposed a tiered molecular testing strategy prioritizing essential and actionable biomarkers. Recommendations were tailored to both public and private healthcare settings and aligned with therapeutic guidance when targeted options are feasible. This consensus provides a practical framework to standardize molecular testing, support clinical decision-making, and promote equitable implementation of precision medicine in pediatric neuro-oncology in Brazil.
Authors
- Kevin Augusto Farias de Alvarenga (ORCID: https://orcid.org/0000-0002-1228-7948)
- Sima Ferman (ORCID: https://orcid.org/0000-0002-7076-6779)
- Felipe D’Almeida Costa (ORCID: https://orcid.org/0000-0002-6470-749X)
- Bruna Minniti Mançano (ORCID: https://orcid.org/0000-0001-7489-4906)
- Gustavo Ramos Teixeira (ORCID: https://orcid.org/0000-0001-8363-3513)
- Israel Gomy (ORCID: https://orcid.org/0000-0002-7926-8477)
- F Martins
- Andréa Maria Cappellano (ORCID: https://orcid.org/0000-0002-3818-8876)
- Marina Rezende da Silveira (ORCID: https://orcid.org/0000-0003-2204-1121)
- Gabriela Oigman Bellas
- Juliana Oliveira de Araújo
- Nicole Souza Silva
- Mariah Rocha Coelho
- Elvis Terci Valera
- Paulo Vidal Campregher
- Oswaldo Keith Okamoto
- Ricardo Camargo
- Jéssica Achilles Pimentel
- Alcânia Pereira dos Reis
- Lauro José Gregianin
Institutions
- Universidade Federal de Minas Gerais (BR)
- Centro Universitário das Faculdades Metropolitanas Unidas (BR)
- Hospital Israelita Albert Einstein (BR)
- AC Camargo Hospital (BR)
- Hospital de Câncer de Barretos (BR)
- Hospital de Clínicas de Porto Alegre (BR)
- Hospital Samaritano de São Paulo (BR)
- Universidade Cidade de São Paulo (BR)
- Hospital Universitário de Brasília (BR)
- Society of Surgical Oncology (US)
- Instituto Nacional de Câncer - INCA (BR)
- Universidade José do Rosário Vellano (BR)
- Clinics Hospital of Ribeirão Preto (BR)
- Universidade Federal de São Paulo (BR)
Publication Details
- Journal
- The Lancet Regional Health - Americas
- Published
- 2026-03-02
- DOI
- https://doi.org/10.1016/j.lana.2026.101422
- Primary Topic
- Glioma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00