A Four-Wavelength Photoplethysmography dataset for non-invasive hemoglobin assessment

Hemoglobin (Hb) concentration is a fundamental physiological marker widely used in the diagnosis of anemia and the assessment of cardiovascular health. Although invasive blood testing provides high accuracy, its reliance on laboratory infrastructure limits scalability and real-time applicability. Here, we present Hb-PPG, a four-wavelength photoplethysmography (PPG) dataset designed to support research on non-invasive hemoglobin assessment and cardiovascular monitoring. The dataset comprises 1008 PPG signal segments acquired at 660, 730, 850, and 940 nm from 252 adult subjects, alongside reference measurements of hemoglobin, fasting blood glucose, and brachial artery systolic and diastolic blood pressure. Hb-PPG enables systematic investigation of wavelength-dependent PPG signal characteristics and their relationships with hematological and hemodynamic parameters. By providing high-quality, multi-wavelength optical signals with clinically grounded reference data, this dataset facilitates the development, validation, and benchmarking of non-invasive approaches for hemoglobin estimation and related vascular health applications. The dataset is intended to support algorithm development, benchmarking, and methodological studies in non-invasive hemoglobin estimation, rather than direct clinical diagnosis.

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Publication Details

Journal
Scientific Data
Published
2026-03-02
DOI
https://doi.org/10.1038/s41597-026-06945-6
Primary Topic
Non-Invasive Vital Sign Monitoring
Type
article
Field-Weighted Citation Impact
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article

A Four-Wavelength Photoplethysmography dataset for non-invasive hemoglobin assessment

Lei Liu, Guanfeng Huang, Shiyong Li, Chen LiangQiu et al.
Scientific Data
Non-Invasive Vital Sign Monitoring
article

A Four-Wavelength Photoplethysmography dataset for non-invasive hemoglobin assessment

Lei Liu, Guanfeng Huang, Shiyong Li, Chen LiangQiu, Yongbo Liang, Yan Zhuang, Zhencheng Chen, Mohamed Elgendi
article en

Abstract

Hemoglobin (Hb) concentration is a fundamental physiological marker widely used in the diagnosis of anemia and the assessment of cardiovascular health. Although invasive blood testing provides high accuracy, its reliance on laboratory infrastructure limits scalability and real-time applicability. Here, we present Hb-PPG, a four-wavelength photoplethysmography (PPG) dataset designed to support research on non-invasive hemoglobin assessment and cardiovascular monitoring. The dataset comprises 1008 PPG signal segments acquired at 660, 730, 850, and 940 nm from 252 adult subjects, alongside reference measurements of hemoglobin, fasting blood glucose, and brachial artery systolic and diastolic blood pressure. Hb-PPG enables systematic investigation of wavelength-dependent PPG signal characteristics and their relationships with hematological and hemodynamic parameters. By providing high-quality, multi-wavelength optical signals with clinically grounded reference data, this dataset facilitates the development, validation, and benchmarking of non-invasive approaches for hemoglobin estimation and related vascular health applications. The dataset is intended to support algorithm development, benchmarking, and methodological studies in non-invasive hemoglobin estimation, rather than direct clinical diagnosis.

Scientific Data
Guangxi Medical University (CN), Khalifa University of Science and Technology (AE), National Supercomputing Center in Wuxi (CN), National Supercomputing Center of Tianjin (CN), Guilin University of Electronic Technology (CN)
National Natural Science Foundation of China, Khalifa University of Science, Technology and Research
Industry, innovation and infrastructure
Openalex Percentile: Top 39%
Non-Invasive Vital Sign Monitoring
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