Increased expression of CD36 and CD163 in clear cell renal cell carcinoma suggests an association between lipid transport and an “M2-like” macrophage phenotype
Lipid metabolic markers CD36 and CD147 are expressed in ccRCC tumors and correlations with immune cell subsets suggest their role in suppressing anti-tumor immunity. These findings suggest the existence of a metabolic-immune axis in ccRCC and provide a rationale for targeting TAM metabolism to enhance immunotherapeutic efficacy.
Authors
- Rahma Said (ORCID: https://orcid.org/0000-0001-6212-3637)
- Christina Bruß
- Agnieszka Martowicz (ORCID: https://orcid.org/0000-0002-5781-9995)
- Simon Engelmann (ORCID: https://orcid.org/0000-0003-3810-3307)
- Yosra Bouraoui
- Sebastian Kaelble
- Florian Weber (ORCID: https://orcid.org/0000-0001-7480-8828)
- G Liebisch
- Roman Mayr
- K Wagner
- Marcus Höring
- Peter J. Siska
Institutions
- University of Augsburg (DE)
- University Hospital Regensburg (DE)
- Tyrolean Cancer Research Institute (AT)
- University of Jendouba (TN)
- University of Regensburg (DE)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-03-02
- DOI
- https://doi.org/10.3389/fimmu.2026.1773666
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Deutscher Akademischer Austauschdienst