Dysregulated interferon signaling and hyperinflammation upon FCGBP knockdown in goat bronchial epithelial cells infected with Pasteurella multocida

The results indicated that FCGBP maintains homeostasis and provides immune protection in goat lungs. Knockdown of FCGBP in goat bronchial epithelial cells leads to impaired cellular barrier function, resulting in excessive activation of type I interferon, HIF-1, TNF, and NOD-like receptor signaling pathways following infection with <i>P. multocida</i>. These findings offer a foundational framework for elucidating the immune function of FCGBP in goat bronchial epithelial cells infected with <i>P. multocida</i>.