PU.1 Inhibition Attenuates Neuroinflammation and Pyroptosis After Traumatic Brain Injury by Modulating Microglial Polarization
PU.1 is a key regulator of neuroinflammation and pyroptosis after TBI. Targeting PU.1 represents a promising therapeutic strategy to mitigate microglial-mediated inflammatory damage and improve outcomes following TBI.
Authors
- F Liu
- Qiu Zb
- Handong Wang (ORCID: https://orcid.org/0000-0002-9116-913X)
- Yijun Cheng
- Sixian Ma
- Feiyu Ding
- Yong Wu
- Lerong Zhang
Institutions
- Shanghai Jiao Tong University (CN)
- Ruijin Hospital (CN)
- Nanjing Brain Hospital (CN)
- Second Affiliated Hospital of Nanjing Medical University (CN)
- Huangshi Central Hospital (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Journal of Craniofacial Surgery
- Published
- 2026-03-02
- DOI
- https://doi.org/10.1097/scs.0000000000012519
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00