Association of the C-reactive protein–triglyceride–glucose index with metabolic dysfunction-associated steatotic liver disease and long-term all-cause and cardiovascular mortality: evidence from two nationwide prospective cohort studies
CTI is a robust metabolic-inflammatory marker associated with MASLD and long-term all-cause and cardiovascular mortality across diverse populations. The strong mediating role of diabetes underscores the central importance of glycaemic dysfunction in cardiometabolic risk. As a readily obtainable index, CTI may aid in cardiometabolic risk stratification among individuals with MASLD.
Authors
- ZI-ZHI LI
- Zhaojie Su
- Xuefeng Jin
- Baojie Shi (ORCID: https://orcid.org/0000-0001-7783-7149)
- Ping Chen (ORCID: https://orcid.org/0000-0003-0274-5674)
- Pan Sun (ORCID: https://orcid.org/0009-0003-6188-7880)
- Yao Xiao (ORCID: https://orcid.org/0000-0002-0194-8253)
- Shiquan Xu
- Yi-Xiang Wang (ORCID: https://orcid.org/0000-0002-5246-5497)
- Z Peng
- Zhenyu Liu
- J Y Ge
- Wen-Hui Tong
- Hao Li
- Xiao-Yan Liu
- Si-Bo Li
- Ping-Sui Li
- Lan-Tian Mao
- Cheng Qiu
- Yang Chen
- Jun-Lin Chen
- Yang-Yang Li
- Xue-Jiao Wen
- Xing Xiong
- Xiang-Rui Kong
- Jian-Fa Zhong
- Tong Zhang
- Hang-Xu Li
Institutions
- Jiangsu University (CN)
- Nanjing University of Chinese Medicine (CN)
- University of Shanghai for Science and Technology (CN)
- Xiamen University (CN)
- Shanghai Chest Hospital (CN)
- Chinese General Hospital College of Nursing and Liberal Arts (PH)
- Soochow University (CN)
- First Affiliated Hospital of Xiamen University (CN)
- Fudan University Shanghai Cancer Center (CN)
- People's Liberation Army No. 150 Hospital (CN)
- Nanjing Drum Tower Hospital (CN)
- Zhongshan Hospital of Xiamen University (CN)
- Shanghai First People's Hospital (CN)
- Beijing Fengtai Hospital (CN)
- Xiamen University of Technology (CN)
- Nanjing Medical University (CN)
- Jinzhou Medical University (CN)
- Nanjing University (CN)
Publication Details
- Journal
- Cardiovascular Diabetology
- Published
- 2026-03-02
- DOI
- https://doi.org/10.1186/s12933-026-03119-x
- Citations
- 2
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 63.04
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Fujian Province
- Xiamen University